Advances in preparation and characterization of chitosan nanoparticles for therapeutics

Artif Cells Nanomed Biotechnol. 2016;44(1):305-14. doi: 10.3109/21691401.2014.948548. Epub 2014 Aug 19.

Abstract

Context: Polymers have been largely explored for the preparation of nanoparticles due to ease of preparation and modification, large gene/drug loading capacity, and biocompatibility. Various methods have been adapted for the preparation and characterization of chitosan nanoparticles.

Objective: Focus on the different methods of preparation and characterization of chitosan nanoparticles.

Methods: Detailed literature survey has been done for the studies reporting various methods of preparation and characterization of chitosan nanoparticles.

Results and conclusion: Published database suggests of several methods which have been developed for the preparation and characterization of chitosan nanoparticles as per the application.

Keywords: chitosan; co-precipitation; ionotropic gelation; microemulsion; nanoparticles; polyelectrolyte complex.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetylation
  • Chemical Precipitation
  • Chitin / chemistry*
  • Chitosan / chemistry*
  • Cross-Linking Reagents / chemistry
  • Drug Carriers / chemistry*
  • Drug Carriers / therapeutic use
  • Emulsions
  • Gels
  • Humans
  • Microscopy / methods
  • Nanoparticles / chemistry*
  • Nanoparticles / therapeutic use
  • Nanoparticles / ultrastructure
  • Particle Size
  • Polyethylene Glycols / chemistry*

Substances

  • Cross-Linking Reagents
  • Drug Carriers
  • Emulsions
  • Gels
  • Chitin
  • Polyethylene Glycols
  • Chitosan