Major depression

Med Clin North Am. 2014 Sep;98(5):981-1005. doi: 10.1016/j.mcna.2014.06.013.

Abstract

Major depression is a common, disabling condition seen frequently in primary care practices. Non-psychiatrist ambulatory providers are increasingly responsible for diagnosing, and primarily managing patients suffering from major depressive disorder (MDD). The goal of this review is to help primary care providers to understand the natural history of MDD, identify practical tools for screening, and a thoughtful approach to management. Clinically challenging topics like co-morbid conditions, treatment resistant depression and pharmacotherapy selection with consideration to side effects and medication interactions, are also covered.

Keywords: Diagnosis; Major depression; Management; Pharmacotherapy; Primary care.

Publication types

  • Review

MeSH terms

  • Adjustment Disorders / diagnosis
  • Alcohol Drinking / adverse effects
  • Antidepressive Agents / therapeutic use
  • Bereavement
  • Depressive Disorder, Major / diagnosis*
  • Depressive Disorder, Major / epidemiology
  • Depressive Disorder, Major / therapy*
  • Diagnosis, Differential
  • Diagnostic and Statistical Manual of Mental Disorders
  • Diet
  • Drug Interactions
  • Drug Resistance
  • Drug-Related Side Effects and Adverse Reactions
  • Exercise
  • Grief
  • Humans
  • Life Style
  • Mass Screening
  • Personality
  • Primary Health Care*
  • Psychotherapy
  • Risk Assessment
  • Risk Factors
  • Selective Serotonin Reuptake Inhibitors / therapeutic use
  • Sleep
  • Sleep Wake Disorders / diagnosis
  • Stress Disorders, Post-Traumatic / diagnosis
  • Substance-Related Disorders / diagnosis
  • Substance-Related Disorders / psychology
  • Suicidal Ideation
  • Surveys and Questionnaires

Substances

  • Antidepressive Agents
  • Serotonin Uptake Inhibitors