Ultrasound-assisted sequential multicomponent strategy for the combinatorial synthesis of novel coumarin hybrids

Selvaraj Kanchithalaivan; Remani Vasudevan Sumesh; Raju Ranjith Kumar

doi:10.1021/co500092b

Ultrasound-assisted sequential multicomponent strategy for the combinatorial synthesis of novel coumarin hybrids

ACS Comb Sci. 2014 Oct 13;16(10):566-72. doi: 10.1021/co500092b. Epub 2014 Aug 27.

Authors

Selvaraj Kanchithalaivan¹, Remani Vasudevan Sumesh, Raju Ranjith Kumar

Affiliation

¹ Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University , Madurai 625 021, Tamil Nadu India.

PMID: 25133700
DOI: 10.1021/co500092b

Abstract

The present investigation reports an easy access to a library of novel spiro-oxindole-pyrrolizine or pyrrolo[1,2-c]thiazole fused coumarin hybrid heterocycles through a one-pot sequential four-component reactions of 2,2-dimethyl-1,3-dioxane-4,6-dione, salicylaldehydes, isatins, and cyclic α-amino acids under ultrasound irradiation.

Keywords: 1,3-dipolar cycloaddition; coumarin; pyrrolizine; pyrrolothiazole; sequential; spiro-oxindole.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acids / chemistry
Combinatorial Chemistry Techniques / methods*
Coumarins / chemical synthesis*
Coumarins / chemistry
Heterocyclic Compounds / chemical synthesis
Indicators and Reagents
Models, Molecular
Molecular Conformation
Spiro Compounds / chemistry
Ultrasonics / methods*

Substances

Amino Acids
Coumarins
Heterocyclic Compounds
Indicators and Reagents
Spiro Compounds