An octadentate bifunctional chelating agent for the development of stable zirconium-89 based molecular imaging probes

Chem Commun (Camb). 2014 Oct 9;50(78):11523-5. doi: 10.1039/c4cc05558f.

Abstract

(89)Zr-based imaging agents hold great promise as novel radio-tracers in nuclear medicine. However, insufficient stability of currently used radiometal complexes in vivo is a safety concern for clinical applications. We herein report the first octadentate bifunctional chelating agent for the development of (89)Zr-labelled (bio)conjugates with improved stability.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Chelating Agents / chemistry*
  • Coordination Complexes / chemical synthesis
  • Coordination Complexes / chemistry*
  • Coordination Complexes / metabolism
  • Crystallography, X-Ray
  • Deferoxamine / chemistry
  • Humans
  • Molecular Conformation
  • Molecular Probes / chemical synthesis
  • Molecular Probes / chemistry*
  • Molecular Probes / metabolism
  • Peptides / chemistry
  • Radiopharmaceuticals / chemical synthesis
  • Radiopharmaceuticals / chemistry
  • Radiopharmaceuticals / metabolism
  • Zirconium / chemistry*

Substances

  • Chelating Agents
  • Coordination Complexes
  • Molecular Probes
  • Peptides
  • Radiopharmaceuticals
  • Zirconium
  • Deferoxamine