Abstract
Core-shell nanoparticles based on fluorescent nanodiamonds coated with a biocompatible N-(2-hydroxypropyl)methacrylamide copolymer shell were developed for background-free near-infrared imaging of cancer cells. The particles showed excellent colloidal stability in buffers and culture media. After conjugation with a cyclic RGD peptide they selectively targeted integrin αvβ3 receptors on glioblastoma cells with high internalization efficacy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acrylamides / chemistry
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Biocompatible Materials / chemistry
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Cell Line, Tumor
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Cell Survival / drug effects
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Click Chemistry
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Endocytosis
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Fluorescent Dyes / chemistry
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Glioma / metabolism
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Glioma / pathology
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Humans
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Integrin alphaVbeta3 / chemistry
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Integrin alphaVbeta3 / metabolism*
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Microscopy, Confocal
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Nanodiamonds / chemistry*
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Nanodiamonds / toxicity
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Peptides, Cyclic / chemistry*
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Peptides, Cyclic / metabolism
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Silicon Dioxide / chemistry
Substances
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Acrylamides
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Biocompatible Materials
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Fluorescent Dyes
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Integrin alphaVbeta3
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Nanodiamonds
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Peptides, Cyclic
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cyclic arginine-glycine-aspartic acid peptide
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Silicon Dioxide
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N-(2-hydroxypropyl)methacrylamide