Designing the nanobiointerface of fluorescent nanodiamonds: highly selective targeting of glioma cancer cells

Nanoscale. 2015 Jan 14;7(2):415-20. doi: 10.1039/c4nr02776k.

Abstract

Core-shell nanoparticles based on fluorescent nanodiamonds coated with a biocompatible N-(2-hydroxypropyl)methacrylamide copolymer shell were developed for background-free near-infrared imaging of cancer cells. The particles showed excellent colloidal stability in buffers and culture media. After conjugation with a cyclic RGD peptide they selectively targeted integrin αvβ3 receptors on glioblastoma cells with high internalization efficacy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylamides / chemistry
  • Biocompatible Materials / chemistry
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Click Chemistry
  • Endocytosis
  • Fluorescent Dyes / chemistry
  • Glioma / metabolism
  • Glioma / pathology
  • Humans
  • Integrin alphaVbeta3 / chemistry
  • Integrin alphaVbeta3 / metabolism*
  • Microscopy, Confocal
  • Nanodiamonds / chemistry*
  • Nanodiamonds / toxicity
  • Peptides, Cyclic / chemistry*
  • Peptides, Cyclic / metabolism
  • Silicon Dioxide / chemistry

Substances

  • Acrylamides
  • Biocompatible Materials
  • Fluorescent Dyes
  • Integrin alphaVbeta3
  • Nanodiamonds
  • Peptides, Cyclic
  • cyclic arginine-glycine-aspartic acid peptide
  • Silicon Dioxide
  • N-(2-hydroxypropyl)methacrylamide