Immunomodulation of human macrophages and myeloid cells by 2-substituted (1-3)-β-D-glucan from P. parvulus 2.6

Carbohydr Polym. 2014 Nov 4:112:109-13. doi: 10.1016/j.carbpol.2014.05.073. Epub 2014 Jun 4.

Abstract

β-glucans produced by eukaryotic cells and by microorganisms are known to modulate immune responses by affecting macrophage activation. Here, we have investigated the effect of purified 2-substituted (1-3)-β-D-glucan, produced by either Pediococcus parvulus 2.6 or Lactococcus lactis NZ9000[pNGTF], on the effector functions of human PMA-differentiated THP-1 cells and M1 pro-inflammatory monocyte-derived macrophages. The results reveal that this kind of β-D-glucan activates macrophages and has an anti-inflammatory effect.

Keywords: 2-Substituted (1–3)-β-d-glucan; Exopolysaccharides; Lactic acid bacteria; Macrophages modulation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cells, Cultured
  • Cytokines / metabolism
  • Humans
  • Immunologic Factors / chemistry
  • Immunologic Factors / pharmacology*
  • Lactococcus lactis / chemistry
  • Lactococcus lactis / genetics
  • Macrophage Activation / drug effects
  • Macrophages / drug effects*
  • Macrophages / immunology
  • Macrophages / metabolism
  • Myeloid Cells / drug effects
  • Pediococcus / chemistry*
  • Polysaccharides, Bacterial / chemistry
  • Polysaccharides, Bacterial / genetics
  • Polysaccharides, Bacterial / isolation & purification
  • Signal Transduction / drug effects
  • beta-Glucans / chemistry*
  • beta-Glucans / pharmacology*

Substances

  • Cytokines
  • Immunologic Factors
  • Polysaccharides, Bacterial
  • beta-Glucans