Abstract
β-glucans produced by eukaryotic cells and by microorganisms are known to modulate immune responses by affecting macrophage activation. Here, we have investigated the effect of purified 2-substituted (1-3)-β-D-glucan, produced by either Pediococcus parvulus 2.6 or Lactococcus lactis NZ9000[pNGTF], on the effector functions of human PMA-differentiated THP-1 cells and M1 pro-inflammatory monocyte-derived macrophages. The results reveal that this kind of β-D-glucan activates macrophages and has an anti-inflammatory effect.
Keywords:
2-Substituted (1–3)-β-d-glucan; Exopolysaccharides; Lactic acid bacteria; Macrophages modulation.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cells, Cultured
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Cytokines / metabolism
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Humans
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Immunologic Factors / chemistry
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Immunologic Factors / pharmacology*
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Lactococcus lactis / chemistry
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Lactococcus lactis / genetics
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Macrophage Activation / drug effects
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Macrophages / drug effects*
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Macrophages / immunology
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Macrophages / metabolism
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Myeloid Cells / drug effects
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Pediococcus / chemistry*
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Polysaccharides, Bacterial / chemistry
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Polysaccharides, Bacterial / genetics
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Polysaccharides, Bacterial / isolation & purification
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Signal Transduction / drug effects
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beta-Glucans / chemistry*
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beta-Glucans / pharmacology*
Substances
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Cytokines
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Immunologic Factors
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Polysaccharides, Bacterial
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beta-Glucans