Diagnosis of major cancer resection specimens with virtual slides: impact of a novel digital pathology workstation

Hum Pathol. 2014 Oct;45(10):2101-6. doi: 10.1016/j.humpath.2014.06.017. Epub 2014 Jul 2.

Abstract

Digital pathology promises a number of benefits in efficiency in surgical pathology, yet the longer time required to review a virtual slide than a glass slide currently represents a significant barrier to the routine use of digital pathology. We aimed to create a novel workstation that enables pathologists to view a case as quickly as on the conventional microscope. The Leeds Virtual Microscope (LVM) was evaluated using a mixed factorial experimental design. Twelve consultant pathologists took part, each viewing one long cancer case (12-25 slides) on the LVM and one on a conventional microscope. Total time taken and diagnostic confidence were similar for the microscope and LVM, as was the mean slide viewing time. On the LVM, participants spent a significantly greater proportion of the total task time viewing slides and revisited slides more often. The unique design of the LVM, enabling real-time rendering of virtual slides while providing users with a quick and intuitive way to navigate within and between slides, makes use of digital pathology in routine practice a realistic possibility. With further practice with the system, diagnostic efficiency on the LVM is likely to increase yet more.

Keywords: Digital pathology; Telepathology; Time to diagnosis; Virtual slides; Whole slide imaging.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Image Processing, Computer-Assisted
  • Microscopy / instrumentation
  • Microscopy / methods
  • Neoplasms / diagnosis*
  • Pathology, Clinical / instrumentation
  • Pathology, Clinical / methods*
  • Pathology, Surgical / instrumentation
  • Pathology, Surgical / methods*
  • Telepathology / instrumentation
  • Telepathology / methods*
  • Time Factors
  • User-Computer Interface*