Cellular immune response in patients with chronic hepatitis B virus infection

Xuefen Li; Yiyin Wang; Yu Chen

doi:10.1016/j.micpath.2014.07.010

Cellular immune response in patients with chronic hepatitis B virus infection

Microb Pathog. 2014 Sep:74:59-62. doi: 10.1016/j.micpath.2014.07.010. Epub 2014 Aug 12.

Authors

Xuefen Li¹, Yiyin Wang¹, Yu Chen²

Affiliations

¹ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, PR China.
² State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, PR China. Electronic address: zychenyu@126.com.

PMID: 25128091
DOI: 10.1016/j.micpath.2014.07.010

Abstract

Hepatitis, cirrhosis and hepatocellular carcinoma caused by hepatitis B virus (HBV) infection has threatening human health seriously. As HBV is a kind of non-cytotoxic virus, host immune response plays a vital role in pathogenesis and clinical outcomes of hepatitis B. Multiple immune cells (e.g., including cytotoxic T lymphocytes, regulatory T cells, natural killer cells, dendritic cells) are important in the immune regulation of HBV infection. Therefore, focusing on the activation states of immune cells may provide new evidences and strategies for determining immune status of HBV infectors, monitoring progression of diseases and predicting efficacy of antiviral treatment.

Keywords: Cellular immune response; Clinical implications; Hepatitis B.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Hepatitis B virus / immunology*
Hepatitis B, Chronic / immunology*
Humans
Immunity, Cellular*