Meroterpenes from Psoralea corylifolia against Pyricularia oryzae

Planta Med. 2014 Oct;80(15):1298-303. doi: 10.1055/s-0034-1382995. Epub 2014 Aug 15.

Abstract

Six new meroterpenes, namely, 13-methoxyisobakuchiol (1), 13-ethoxyisobakuchiol (2), 12,13-dihydro-13-hydroxybakuchiol (3), Δ(10)-12,13-dihydro-12-(R,S)-methoxyisobakuchiol (4 and 5), and 15-demetyl-12,13-dihydro-13-ketobakuchiol (6), together with four known ones, namely, Δ(3),2-hydroxybakuchiol (7), Δ(1),3-hydroxybakuchiol (8), bakuchiol (9), and Δ(1,3)-bakuchiol (10), were isolated from the seeds of Psoralea corylifolia. Their structures were identified based on spectral data, including those obtained via 1D and 2D NMR, and MS spectral analyses. Antifungal screening results indicated that all compounds showed moderate inhibitory activities against Pyricularia oryzae.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology*
  • Magnaporthe / drug effects*
  • Magnaporthe / pathogenicity
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Phenols / isolation & purification
  • Phenols / pharmacology
  • Psoralea / chemistry*
  • Seeds / chemistry
  • Terpenes / chemistry*
  • Terpenes / isolation & purification
  • Terpenes / pharmacology*

Substances

  • Antifungal Agents
  • Phenols
  • Terpenes
  • delta(3),2-hydroxybakuchiol
  • bakuchiol