Phorbaketals L-N, cytotoxic sesterterpenoids isolated from the marine sponge of the genus Phorbas

Bioorg Med Chem Lett. 2014 Sep 1;24(17):4095-8. doi: 10.1016/j.bmcl.2014.07.066. Epub 2014 Jul 30.

Abstract

Three new sesterterpenoids, phorbaketals L-N (1-3), were isolated from a marine sponge of the genus Phorbas and their complete structures were elucidated via analysis of HRFABMS and NMR spectroscopic data. Phorbaketal N (3) showed potent cytotoxicity against human pancreas cancer cells (IC50=11.4 μM).

Keywords: Cytotoxicity; Phorbaketals; Phorbas sp..

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Dose-Response Relationship, Drug
  • Humans
  • Molecular Structure
  • Pancreatic Neoplasms / pathology*
  • Porifera / chemistry*
  • Sesterterpenes / chemistry
  • Sesterterpenes / isolation & purification
  • Sesterterpenes / toxicity*
  • Structure-Activity Relationship

Substances

  • Sesterterpenes