Abstract
We investigated Pneumocystis jirovecii dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR) genes for mutations in 25 Chinese HIV-infected patients with P. jirovecii pneumonia. We identified DHPS mutations in 3 (12%) patients and DHFR mutations in 1 (4%) patient. The prevalence of DHPS and DHFR mutations in China remains low, as it does in other developing countries.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.
Publication types
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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China
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Dihydropteroate Synthase / genetics*
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Female
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HIV Infections / complications*
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Humans
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Male
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Middle Aged
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Mutant Proteins / genetics
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Mutation*
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Pneumocystis carinii / enzymology*
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Pneumocystis carinii / genetics
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Prevalence
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Tetrahydrofolate Dehydrogenase / genetics*
Substances
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Mutant Proteins
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Tetrahydrofolate Dehydrogenase
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Dihydropteroate Synthase