Epstein-Barr virus-associated lymphoepithelioma-like gastric carcinoma located on gastric high body: two case reports

Indian J Pathol Microbiol. 2014 Jul-Sep;57(3):463-6. doi: 10.4103/0377-4929.138775.

Abstract

Lymphoepithelioma-like gastric carcinoma (LELGC) is a rare neoplasm of the stomach with an incidence of 1-4% of all gastric cancers. It is characterized by the presence of a lymphoid stroma with cells arranged primarily in micro alveolar, thin trabecular, and primitive tubular patterns or isolated cells. It is one of the histological patterns observed in patients with Epstein - Barr virus (EBV)-associated gastric carcinoma (EBVaGC). In situ hybridization was usually used to confirm the presence of EBV. There are two types of EBVaGC, LELGC, and ordinary type. Approximately, 15-25% of EBVaGC exhibit the LELGC pattern. Here, we described two cases of LELGC and the related literatures were reviewed as well. The two cases were submucosal mass from a 59- or 63-year-old man. We found LELGC has special clinicopathologic features and protein expression profile. This should promote us to make a true diagnosis.

Publication types

  • Case Reports

MeSH terms

  • Biomarkers, Tumor / analysis
  • Cadherins / analysis
  • DNA (Cytosine-5-)-Methyltransferase 1
  • DNA (Cytosine-5-)-Methyltransferases / biosynthesis
  • DNA, Viral / genetics
  • Epstein-Barr Virus Infections / complications*
  • Herpesvirus 4, Human / genetics
  • Histocytochemistry
  • Humans
  • Immunohistochemistry
  • Lymphoma / diagnosis*
  • Lymphoma / pathology*
  • Male
  • Microscopy
  • Middle Aged
  • Nucleic Acid Hybridization
  • Stomach Neoplasms / diagnosis*
  • Stomach Neoplasms / pathology*
  • beta Catenin / analysis

Substances

  • Biomarkers, Tumor
  • Cadherins
  • DNA, Viral
  • beta Catenin
  • DNA (Cytosine-5-)-Methyltransferase 1
  • DNA (Cytosine-5-)-Methyltransferases