Formulating the magic bullet: barriers to clinical translation of nanoparticle cancer gene therapy

Nanomedicine (Lond). 2014;9(8):1121-4. doi: 10.2217/nnm.14.63.
No abstract available

Keywords: EPR; PEG; PEI; cancer; enhanced permeability and retention effect; gene delivery; gene therapy; nanoparticles; polyethylene glycol; polyethylenimine; transfection.

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Gene Transfer Techniques*
  • Genetic Therapy* / methods
  • Humans
  • Nanomedicine / methods
  • Nanoparticles / chemistry*
  • Nanoparticles / metabolism
  • Nanoparticles / toxicity
  • Neoplasms / therapy*
  • Polyethylene Glycols / chemistry
  • Polyethylene Glycols / metabolism
  • Polyethylene Glycols / toxicity
  • Polyethyleneimine / chemistry
  • Polyethyleneimine / metabolism
  • Polyethyleneimine / toxicity

Substances

  • Polyethylene Glycols
  • Polyethyleneimine