A role for β3-integrins in linking breast development and cancer

Dev Cell. 2014 Aug 11;30(3):251-2. doi: 10.1016/j.devcel.2014.07.009.

Abstract

Pregnancy induces a rapid and controlled expansion of mammary stem cells. In this issue of Developmental Cell, Desgrosellier et al. (2014) show that β3-integrin is required downstream of hormonal signaling and TGFβ2 to regulate mammary stem cell number and alveolar development specifically during early pregnancy.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic / metabolism*
  • Female
  • Humans
  • Integrin alphaVbeta3 / metabolism*
  • Mammary Glands, Animal / cytology*
  • Pregnancy
  • Snail Family Transcription Factors
  • Stem Cells / cytology*
  • Transcription Factors / metabolism*

Substances

  • Integrin alphaVbeta3
  • Snail Family Transcription Factors
  • Transcription Factors