The calcium ion (Ca(2+)) is the main common second messenger involved in signaling transduction subsequent to immunoreceptor activation. Its rapid intracellular elevation induces multiple cellular responses, such as secretion, proliferation, mobility, and gene transcription. Intracellular levels of Ca(2+) need to reach a specific threshold to efficiently transduce the signal to activate transcription factors through the recruitment of Ca(2+)-binding molecules. However, since Ca(2+) cannot be metabolized, its intracellular concentration is tightly regulated to avoid the induction of programmed cell death. This highly controlled regulation of Ca(2+) homeostasis has recently been clarified by the uncovering of new ion channels. The regulation of these channels allows the role of Ca(2+) in Fc receptor transduction pathways to be more precisely defined.