Two new cyclic dipeptides from Rhinocladiella sp. lgt-3, a fungal endophyte isolated from Tripterygium wilfordii Hook

Nat Prod Res. 2014;28(20):1760-4. doi: 10.1080/14786419.2014.945176. Epub 2014 Aug 12.

Abstract

Two new cyclic dipeptides, rhinocladin A (1) and rhinocladin B (2), were isolated from a fungal endophyte (Rhinocladiella sp. lgt-3) of Tripterygium wilfordii Hook. Their structures were elucidated by 1D and 2D NMR spectra. The monoamine oxidase inhibitory activity of 1 and 2 was also evaluated.

Keywords: Rhinocladiella; Tripterygiun wilfordii; cyclic dipeptides; endophyte; monoamine oxidase inhibitors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dipeptides / chemistry*
  • Dipeptides / isolation & purification
  • Endophytes / chemistry
  • Magnetic Resonance Spectroscopy
  • Mitosporic Fungi / chemistry*
  • Molecular Structure
  • Monoamine Oxidase Inhibitors / chemistry
  • Monoamine Oxidase Inhibitors / isolation & purification
  • Peptides, Cyclic / chemistry*
  • Peptides, Cyclic / isolation & purification
  • Tripterygium / microbiology*

Substances

  • Dipeptides
  • Monoamine Oxidase Inhibitors
  • Peptides, Cyclic
  • rhinocladin A
  • rhinocladin B