Effects of midazolam on fentanyl antinociception and respiration in a rabbit model

J Hyatt; C Coro; S A Bergman; R L Wynn

doi:10.1016/0278-2391(89)90728-3

Effects of midazolam on fentanyl antinociception and respiration in a rabbit model

J Oral Maxillofac Surg. 1989 Dec;47(12):1298-302. doi: 10.1016/0278-2391(89)90728-3.

Authors

J Hyatt¹, C Coro, S A Bergman, R L Wynn

Affiliation

¹ Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland.

PMID: 2511288
DOI: 10.1016/0278-2391(89)90728-3

Abstract

Clinical antinociception is difficult to assess because of difficulties with controls and the incorporation of bias. The rabbit antinociceptive model is highly sensitive and predictive of analgesia in humans. We found that the combination of midazolam with fentanyl enhanced antinociception compared with fentanyl alone. In addition, with this model there were relatively unimportant increases in respiratory depression.

MeSH terms

Analgesics*
Animals
Carbon Dioxide / blood
Drug Combinations
Electric Stimulation
Female
Fentanyl / administration & dosage
Fentanyl / pharmacology*
Infusions, Intravenous
Male
Midazolam / administration & dosage
Midazolam / pharmacology*
Naloxone / pharmacology
Rabbits
Respiration / drug effects*
Respiratory Insufficiency / chemically induced

Substances

Analgesics
Drug Combinations
Carbon Dioxide
Naloxone
Midazolam
Fentanyl