Balance of apoptotic cell death and survival in allergic diseases

Bao-Ping Tian; Hong-Bin Zhou; Li-Xia Xia; Hua-Hao Shen; Songmin Ying

doi:10.1016/j.micinf.2014.07.004

Balance of apoptotic cell death and survival in allergic diseases

Microbes Infect. 2014 Oct;16(10):811-21. doi: 10.1016/j.micinf.2014.07.004. Epub 2014 Aug 8.

Authors

Bao-Ping Tian¹, Hong-Bin Zhou¹, Li-Xia Xia¹, Hua-Hao Shen², Songmin Ying³

Affiliations

¹ Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China; Key Site of National Clinical Research Center for Respiratory Disease, Hangzhou, Zhejiang 310058, China.
² Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China; Key Site of National Clinical Research Center for Respiratory Disease, Hangzhou, Zhejiang 310058, China; State Key Laboratory of Respiratory Diseases, Guangzhou, Guangdong 510120, China. Electronic address: huahaoshen@zju.edu.cn.
³ Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China; Key Site of National Clinical Research Center for Respiratory Disease, Hangzhou, Zhejiang 310058, China; Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China. Electronic address: yings@zju.edu.cn.

PMID: 25111826
DOI: 10.1016/j.micinf.2014.07.004

Abstract

Allergic diseases result from over-reaction of the immune system in response to exogenous allergens, where inflammatory cells have constantly extended longevity and contribute to an on-going immune response in allergic tissues. Here, we review disequilibrium in the death and survival of epithelial cells and inflammatory cells in the pathological processes of asthma, atopic dermatitis, and other allergic diseases.

Keywords: Allergic disease; Apoptosis; Cell death; Epithelial cells; Inflammatory cells.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Allergens / immunology
Animals
Apoptosis*
Cell Survival*
Disease Models, Animal
Epithelial Cells / cytology
Epithelial Cells / metabolism
Granulocytes / cytology
Granulocytes / metabolism
Humans
Hypersensitivity, Immediate / immunology*
Hypersensitivity, Immediate / pathology
Mast Cells / cytology
Mast Cells / metabolism
Monocytes / cytology
Monocytes / metabolism

Substances

Allergens