Dramatic lowering of very high Lp(a) in response to niacin

Min Li; Ramesh Saeedi; Simon W Rabkin; Jiri Frohlich

doi:10.1016/j.jacl.2014.03.006

Dramatic lowering of very high Lp(a) in response to niacin

J Clin Lipidol. 2014 Jul-Aug;8(4):448-50. doi: 10.1016/j.jacl.2014.03.006. Epub 2014 Mar 30.

Authors

Min Li¹, Ramesh Saeedi¹, Simon W Rabkin¹, Jiri Frohlich²

Affiliations

¹ Healthy Heart Program Prevention Clinic, St. Paul's Hospital, Vancouver, BC, Canada.
² Healthy Heart Program Prevention Clinic, St. Paul's Hospital, Vancouver, BC, Canada. Electronic address: jifr@mail.ubc.ca.

PMID: 25110227
DOI: 10.1016/j.jacl.2014.03.006

Abstract

We describe a patient with markedly elevated lipoprotein(a) (Lp(a)) without any other lipid abnormalities. After a myocardial infarction, she was treated with combination of extended-release niacin and statin. An 88% reduction in Lp(a) was observed during 5 years of treatment, which is much better response than usually reported.

Keywords: Coronary artery disease (CAD); Lipoprotein(a) [Lp(a)]; Niacin; Statin.

Publication types

Case Reports

MeSH terms

Atorvastatin
Biomarkers / metabolism*
Coronary Artery Disease / complications
Coronary Artery Disease / diagnosis*
Coronary Artery Disease / drug therapy
Disease-Free Survival
Female
Heptanoic Acids / therapeutic use*
Humans
Hypolipidemic Agents / therapeutic use*
Lipoprotein(a) / metabolism*
Middle Aged
Myocardial Infarction / diagnosis*
Myocardial Infarction / drug therapy
Myocardial Infarction / etiology
Niacin / therapeutic use*
Pyrroles / therapeutic use*
Risk

Substances

Biomarkers
Heptanoic Acids
Hypolipidemic Agents
Lipoprotein(a)
Pyrroles
Niacin
Atorvastatin