The truncated RUNX1/ETO activates VLA-4-dependent adhesion and migration of hematopoietic progenitor cells

Haematologica. 2014 Dec;99(12):e253-6. doi: 10.3324/haematol.2014.106088. Epub 2014 Aug 8.
No abstract available

Keywords: RUNX1/ETO; VLA-4; adhesion; integrin; leukemia; migration.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Adhesion / physiology*
  • Cell Movement / physiology*
  • Core Binding Factor Alpha 2 Subunit / genetics
  • Core Binding Factor Alpha 2 Subunit / metabolism*
  • Flow Cytometry
  • Hematopoietic Stem Cells / cytology*
  • Hematopoietic Stem Cells / metabolism
  • Humans
  • Integrin alpha4beta1 / genetics
  • Integrin alpha4beta1 / metabolism*
  • Leukemia, Experimental / metabolism
  • Leukemia, Experimental / pathology*
  • Mice
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / metabolism*
  • RUNX1 Translocation Partner 1 Protein
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*

Substances

  • Core Binding Factor Alpha 2 Subunit
  • Integrin alpha4beta1
  • Proto-Oncogene Proteins
  • RUNX1 Translocation Partner 1 Protein
  • RUNX1 protein, human
  • RUNX1T1 protein, human
  • Transcription Factors