Comparison of 2 Methods of Local Anesthetic-Based Injection as Part of a Multimodal Approach to Pain Management After Total Knee Arthroplasty

J Pharm Pract. 2015 Dec;28(6):523-8. doi: 10.1177/0897190014544815. Epub 2014 Aug 8.

Abstract

Background: It is estimated that up to 50% of patients undergoing total knee arthroplasty (TKA) receive suboptimal postoperative pain management.

Methods: In a retrospective study, 224 patients who underwent TKA between January 1, 2011, and September 30, 2012, were identified by surgical records for 2 surgeons at Community Medical Center in Missoula, Montana. Patient records were reviewed and data collected for patient hospital length of stay (LOS), postoperative opioid use, opioid-associated adverse events, and nonopioid analgesic use. Data were analyzed for differences in outcomes between patients who received an intraoperative intra-articular (IOIA) injection followed by a postoperative infusion (0.25%-0.5% bupivacaine) or an intraoperative periarticular (IOPA) injection (ropivacaine, ketorolac, epinephrine, and clonidine) for sustained analgesia after TKA.

Results: Patients who received an IOPA injection had a statistically significant decrease in hospital LOS (67.0 vs 75.9 hours; P = .027) and postoperative nausea and vomiting (39.3% vs 54.9%; P = .023) when compared to patients who received an IOIA infusion. The incidence of having either oversedation or pruritus did not differ between groups (9.8% vs 9.8%; P = 1.00).

Conclusion: The use of IOPA injections containing ropivacaine, epinephrine, ketorolac, and clonidine during TKA offered some benefit over IOIA infusions containing 0.25% to 0.5% bupivacaine at our institution.

Keywords: analgesia; intraarticular infusion; multimodal analgesia; periarticular injection; total knee arthroplasty.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Amides / administration & dosage
  • Amides / adverse effects
  • Amides / therapeutic use
  • Analgesics / administration & dosage
  • Analgesics / adverse effects
  • Analgesics / therapeutic use
  • Anesthetics, Local / administration & dosage*
  • Anesthetics, Local / adverse effects
  • Anesthetics, Local / therapeutic use*
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Arthroplasty, Replacement, Knee*
  • Bupivacaine / administration & dosage
  • Bupivacaine / adverse effects
  • Bupivacaine / therapeutic use
  • Clonidine / administration & dosage
  • Clonidine / adverse effects
  • Clonidine / therapeutic use
  • Drug Administration Routes
  • Drug Therapy, Combination / adverse effects
  • Epinephrine / administration & dosage
  • Epinephrine / adverse effects
  • Epinephrine / therapeutic use
  • Female
  • Humans
  • Ketorolac / administration & dosage
  • Ketorolac / adverse effects
  • Ketorolac / therapeutic use
  • Length of Stay / statistics & numerical data
  • Male
  • Montana / epidemiology
  • Pain Management / methods*
  • Postoperative Nausea and Vomiting / chemically induced
  • Postoperative Nausea and Vomiting / epidemiology
  • Retrospective Studies
  • Ropivacaine
  • Vasoconstrictor Agents / administration & dosage
  • Vasoconstrictor Agents / adverse effects
  • Vasoconstrictor Agents / therapeutic use

Substances

  • Amides
  • Analgesics
  • Anesthetics, Local
  • Anti-Inflammatory Agents, Non-Steroidal
  • Vasoconstrictor Agents
  • Ropivacaine
  • Clonidine
  • Bupivacaine
  • Epinephrine
  • Ketorolac