Prescription of alendronate and risedronate in men: off-label use in a health area
Reumatol Clin. 2015 Mar-Apr;11(2):64-7.
doi: 10.1016/j.reuma.2014.05.003.
Epub 2014 Aug 6.
[Article in
English,
Spanish]
Affiliations
- 1 Centro de Salud Universitario San Juan de la Cruz, Pozuelo de Alarcón, Madrid, España. Electronic address: fleonvaz@gmail.com.
- 2 Servicio de Farmacia, Dirección Asistencial Noroeste, Gerencia de Atención Primaria, Servicio Madrileño de Salud, Majadahonda, Madrid, España.
- 3 Centro de Salud Universitario San Juan de la Cruz, Pozuelo de Alarcón, Madrid, España.
- 4 Unidad Docente Multidisciplinar de Atención Familiar y Comunitaria, Dirección Asistencial Noroeste, Gerencia de Atención Primaria, Servicio Madrileño de Salud, Majadahonda, Madrid, España.
Abstract
Background and objective:
Alendronate and risedronate are both effective and safe treatments for osteoporosis in men, but only risedronate has this indication in its data-sheet. We compared their use by gender.
Patient and methods:
Retrospective descriptive study of prescriptions of risedronate and alendronate in 2012 in primary care in the northwest area of the Community of Madrid. We compared patients and defined daily doses (DDD) dispensed by gender.
Results:
14.857 patients used 1.847.370 DDD of alendronate or risedronate, 1.145 (7.7%) patients were men. In women alendronate was most prescribed (55% vs. 45%) than risedronate. Risedronate was preferred in men, 47.6% vs. 52.4%, resulting in a statistically significant difference (P<.001).
Conclusions:
Risedronate is preferred to alendronate in men, which is often used off-label, despite the existence of alternatives.
Keywords:
Alendronate; Male; Off-label use; Osteoporosis/drug therapy; Osteoporosis/tratamiento farmacológico; Risedronate; Uso fuera de ficha técnica; Varón; Ácido alendrónico; Ácido risedrónico.
Copyright © 2014 Elsevier España, S.L.U. All rights reserved.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Alendronate / therapeutic use*
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Bone Density Conservation Agents / therapeutic use*
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Drug Administration Schedule
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Female
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Humans
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Male
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Off-Label Use / statistics & numerical data*
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Osteoporosis / drug therapy*
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Osteoporosis, Postmenopausal / drug therapy
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Practice Patterns, Physicians' / statistics & numerical data*
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Retrospective Studies
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Risedronic Acid / therapeutic use*
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Sex Factors
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Spain
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Treatment Outcome
Substances
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Bone Density Conservation Agents
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Risedronic Acid
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Alendronate