Genetic diversity and population structure of Plasmodium vivax isolates from Sudan, Madagascar, French Guiana and Armenia

Infect Genet Evol. 2014 Oct:27:244-9. doi: 10.1016/j.meegid.2014.07.029. Epub 2014 Aug 4.

Abstract

Polymorphic genetic markers and especially microsatellite analysis can be used to investigate multiple aspects of the biology of Plasmodium species. In the current study, we characterized 7 polymorphic microsatellites in a total of 281 Plasmodium vivax isolates to determine the genetic diversity and population structure of P. vivax populations from Sudan, Madagascar, French Guiana, and Armenia. All four parasite populations were highly polymorphic with 3-32 alleles per locus. Mean genetic diversity values was 0.83, 0.79, 0.78 and 0.67 for Madagascar, French Guiana, Sudan, and Armenia, respectively. Significant genetic differentiation between all four populations was observed.

Keywords: Armenia; French Guiana; Madagascar; Microsatellite analysis; Plasmodium vivax; Sudan.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Armenia
  • French Guiana
  • Genetic Loci
  • Genetic Markers
  • Genetic Variation*
  • Genetics, Population
  • Heterozygote
  • Humans
  • Linkage Disequilibrium
  • Madagascar
  • Malaria, Vivax / epidemiology
  • Malaria, Vivax / parasitology*
  • Microsatellite Repeats
  • Plasmodium vivax / genetics*
  • Plasmodium vivax / isolation & purification
  • Spatio-Temporal Analysis
  • Sudan

Substances

  • Genetic Markers