Abstract
A novel approach for multivalent targeting by using gold nanoparticles noncovalently decorated by tight functionalization with a cone-glycocalixarene bearing four mannose units is reported. The targeting efficiency of these multivalent nanoparticles is shown to be remarkably improved compared to that of nanoparticles bearing a monovalent mannosylated derivative.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies / chemistry
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Antibodies / immunology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Apoptosis / drug effects
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Calixarenes / chemistry*
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Gold / chemistry*
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HeLa Cells
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Humans
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Mannose / chemistry
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Metal Nanoparticles / chemistry*
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Nanoconjugates / chemistry*
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Peptides / chemistry
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Peptides / metabolism
Substances
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Antibodies
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Antineoplastic Agents
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Nanoconjugates
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Peptides
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Calixarenes
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Gold
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Mannose