Abstract
Inhibiting Notch signaling induces adipose browning, improves systemic glucose tolerance and insulin sensitivity, and suppresses weight gain in mice.
MeSH terms
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Adipose Tissue, Brown / drug effects*
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Adipose Tissue, White / drug effects*
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Animals
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Female
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Immunoglobulin J Recombination Signal Sequence-Binding Protein / antagonists & inhibitors*
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Male
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Obesity / therapy*
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Receptor, Notch1 / antagonists & inhibitors*
Substances
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Immunoglobulin J Recombination Signal Sequence-Binding Protein
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Notch1 protein, mouse
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Rbpj protein, mouse
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Receptor, Notch1