Lightening up a notch: Notch regulation of energy metabolism

Nat Med. 2014 Aug;20(8):811-2. doi: 10.1038/nm.3650.

Abstract

Inhibiting Notch signaling induces adipose browning, improves systemic glucose tolerance and insulin sensitivity, and suppresses weight gain in mice.

Publication types

  • Comment

MeSH terms

  • Adipose Tissue, Brown / drug effects*
  • Adipose Tissue, White / drug effects*
  • Animals
  • Female
  • Immunoglobulin J Recombination Signal Sequence-Binding Protein / antagonists & inhibitors*
  • Male
  • Obesity / therapy*
  • Receptor, Notch1 / antagonists & inhibitors*

Substances

  • Immunoglobulin J Recombination Signal Sequence-Binding Protein
  • Notch1 protein, mouse
  • Rbpj protein, mouse
  • Receptor, Notch1