A protracted and aggressive variant of lymphocytic hypophysitis with mammillary body involvement and cognitive dysfunction

Adrienne Dow; Ruth Virginia Russell; Vivien Bonert; John Carmichael; Adam Mamelak; Barry D Pressman; Xuemo Fan; Run Yu

doi:10.4158/EP14202.CR

A protracted and aggressive variant of lymphocytic hypophysitis with mammillary body involvement and cognitive dysfunction

Endocr Pract. 2014 Nov;20(11):e225-9. doi: 10.4158/EP14202.CR.

Authors

Adrienne Dow¹, Ruth Virginia Russell², Vivien Bonert², John Carmichael², Adam Mamelak³, Barry D Pressman⁴, Xuemo Fan⁵, Run Yu²

Affiliations

¹ Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California.
² Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, California.
³ Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, California.
⁴ Department of Imaging, Cedars Sinai Medical Center, Los Angeles, California.
⁵ Department of Pathology, Cedars Sinai Medical Center, Los Angeles, California.

PMID: 25100390
DOI: 10.4158/EP14202.CR

Abstract

Objective: Our objective was to describe the 14-year course of a patient with a protracted and aggressive variant of lymphocytic hypophysitis.

Methods: This is a case report.

Results: Despite several trials of pulse steroids, this young female patient demonstrated persistent inflammation of the pituitary gland with eventual extension into the mammillary bodies with clinical cognitive decline. To our knowledge, there is no other reported case of lymphocytic hypophysitis with autoimmune inflammation extending beyond the infundibulum.

Conclusion: This case broadens the clinical spectrum of lymphocytic hypophysitis.

Publication types

Case Reports

MeSH terms

Autoimmune Hypophysitis*
Cognitive Dysfunction*
Female
Humans
Hypopituitarism*
Inflammation
Mammillary Bodies
Pituitary Gland