Abstract
Seven new clerodane diterpenoids, dysoxydensins A-G (1-7), together with six known clerodanes, were isolated from Dysoxylum densiflorum. The structures of all the compounds were elucidated by extensive spectroscopic analysis. These compounds were evaluated for their cytotoxic activities against five human cancer cell lines, and compounds 2, 3, and 5 showed moderate cytotoxic activities.
Georg Thieme Verlag KG Stuttgart · New York.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Antineoplastic Agents, Phytogenic / therapeutic use
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Cell Line, Tumor
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Diterpenes, Clerodane / chemistry
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Diterpenes, Clerodane / isolation & purification*
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Diterpenes, Clerodane / pharmacology
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Diterpenes, Clerodane / therapeutic use
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Humans
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Meliaceae / chemistry*
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Molecular Structure
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Neoplasms / drug therapy
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Phytotherapy
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Plant Extracts / chemistry
Substances
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Antineoplastic Agents, Phytogenic
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Diterpenes, Clerodane
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Plant Extracts