Nanometer-sized manganese oxide-quenched fluorescent oligonucleotides: an effective sensing platform for probing biomolecular interactions

Chem Commun (Camb). 2014 Sep 28;50(75):11049-52. doi: 10.1039/c4cc04573d. Epub 2014 Aug 7.

Abstract

We propose a novel template-assisted strategy to prepare nanometer-sized manganese oxide (nano-MnO2) by self-assembly of some MnO2 platelets and demonstrate its application as a new class of biosensing platform for probing DNA hybridization and aptamer-target interaction in a homogeneous solution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aptamers, Nucleotide / chemistry
  • Biosensing Techniques
  • DNA / analysis
  • DNA, Single-Stranded / chemistry
  • DNA, Single-Stranded / metabolism
  • Fluorescence Resonance Energy Transfer
  • Fluorescent Dyes / chemistry
  • Manganese Compounds / chemistry*
  • Nanostructures / chemistry*
  • Nucleic Acid Hybridization
  • Oligonucleotides / chemistry*
  • Oligonucleotides / metabolism
  • Oxides / chemistry*
  • Particle Size
  • Static Electricity
  • Surface-Active Agents / chemistry

Substances

  • Aptamers, Nucleotide
  • DNA, Single-Stranded
  • Fluorescent Dyes
  • Manganese Compounds
  • Oligonucleotides
  • Oxides
  • Surface-Active Agents
  • manganese oxide
  • DNA