Characterization of a novel highly pathogenic H5N2 avian influenza virus isolated from a duck in eastern China

Arch Virol. 2014 Dec;159(12):3377-83. doi: 10.1007/s00705-014-2193-1. Epub 2014 Aug 5.

Abstract

During surveillance for avian influenza viruses (AIVs) in live-poultry markets (LPMs) in eastern China in 2013, one H5N2 AIV was isolated from a duck. Phylogenetic analysis showed that the hemagglutinin of this strain belongs to clade 2.3.4 and received its genes from H5, H3 and H6 AIVs of poultry in China. The virulence of this strain was examined in chickens and mice, and it was found to be highly pathogenic in chickens but demonstrated moderate pathogenicity in mice. These results suggest that active surveillance of AIVs in LPMs should be used in an early warning system for avian influenza outbreaks.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chickens
  • China
  • Cluster Analysis
  • Disease Models, Animal
  • Ducks / virology*
  • Evolution, Molecular
  • Hemagglutinin Glycoproteins, Influenza Virus / genetics
  • Influenza A Virus, H5N2 Subtype / classification*
  • Influenza A Virus, H5N2 Subtype / genetics
  • Influenza A Virus, H5N2 Subtype / isolation & purification*
  • Influenza A Virus, H5N2 Subtype / pathogenicity
  • Influenza in Birds / pathology
  • Influenza in Birds / virology*
  • Mice
  • Molecular Sequence Data
  • Orthomyxoviridae Infections / pathology
  • Orthomyxoviridae Infections / virology
  • Phylogeny
  • RNA, Viral / genetics
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid
  • Virulence

Substances

  • Hemagglutinin Glycoproteins, Influenza Virus
  • RNA, Viral

Associated data

  • GENBANK/KJ933374
  • GENBANK/KJ933375
  • GENBANK/KJ933376
  • GENBANK/KJ933377
  • GENBANK/KJ933378
  • GENBANK/KJ933379
  • GENBANK/KJ933380
  • GENBANK/KJ933381