The constituents of roots and stems of Illigera luzonensis and their anti-platelet aggregation effects

Int J Mol Sci. 2014 Jul 31;15(8):13424-36. doi: 10.3390/ijms150813424.

Abstract

Phytochemical investigation of the roots and stems of Illigera luzonensis afforded two new aporphine alkaloids (1) and (2), one new bisdehydroaporphine alkaloid (3), and one new benzenoid (4), along with 28 known structures. The structures of new compounds were elucidated by spectral and MS analysis. Among the isolated compounds, (1) and (4-13) were subjected into the examination for their inhibitory effects on the aggregation of washed rabbit platelets.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification
  • Alkaloids / pharmacology
  • Animals
  • Aporphines / chemistry
  • Hernandiaceae / chemistry*
  • Hernandiaceae / metabolism
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Roots / chemistry
  • Plant Roots / metabolism
  • Plant Stems / chemistry
  • Plant Stems / metabolism
  • Platelet Aggregation / drug effects*
  • Platelet Aggregation Inhibitors / pharmacology
  • Rabbits

Substances

  • Alkaloids
  • Aporphines
  • Plant Extracts
  • Platelet Aggregation Inhibitors
  • aporphine