Co-stimulation with interleukin-4 and tumor necrosis factor-α increases epidermal innervation accompanied by suppression of semaphorin 3A

J Dermatol Sci. 2014 Oct;76(1):69-71. doi: 10.1016/j.jdermsci.2014.06.005. Epub 2014 Jul 4.

Authors

Takashi Sakai¹, Daisuke Takahashi¹, Kousei Nikaido¹, Kanako Okauchi¹, Naomi Mori¹, Ryosuke Irie¹, Yutaka Hatano², Sakuhei Fujiwara¹

Affiliations

¹ Department of Dermatology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita 879-5593, Japan.
² Department of Dermatology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita 879-5593, Japan. Electronic address: hatano@oita-u.ac.jp.

PMID: 25088775
DOI: 10.1016/j.jdermsci.2014.06.005

No abstract available

Keywords: Epidermal innervation; IL-4; NGF; Sema3A; TNF-α.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Dermatitis, Atopic / immunology*
Dermatitis, Atopic / metabolism
Epidermis / innervation*
Epidermis / metabolism
Immunohistochemistry
Inflammation
Interleukin-4 / pharmacology*
Mice
Mice, Inbred C57BL
Nerve Growth Factor / metabolism
STAT6 Transcription Factor / metabolism*
Semaphorin-3A / metabolism*
Skin / drug effects*
Tumor Necrosis Factor-alpha / pharmacology*

Substances

STAT6 Transcription Factor
Semaphorin-3A
Stat6 protein, mouse
Tumor Necrosis Factor-alpha
Interleukin-4
Nerve Growth Factor