Highly enantioselective [3+2] coupling of indoles with quinone monoimines promoted by a chiral phosphoric acid

Abstract

Highly enantioselective [3+2] coupling of 3-substituted indoles with quinone monoimines promoted by a chiral phosphoric acid has been reported. A large variety of benzofuroindolines were prepared in moderate to good yields (up to 98%) with generally excellent enantioselectivities (up to 99% ee).

Keywords: asymmetric catalysis; enantioselectivity; heterocycles; indoles; organocatalysis.