Cu(II)-mediated ortho C-H alkynylation of (hetero)arenes with terminal alkynes

J Am Chem Soc. 2014 Aug 20;136(33):11590-3. doi: 10.1021/ja507704b. Epub 2014 Aug 6.

Abstract

Cu(II)-promoted ortho alkynylation of arenes and heteroarenes with terminal alkynes has been developed to prepare aryl alkynes. A variety of arenes and terminal alkynes bearing different substituents are compatible with this reaction, thus providing an alternative disconnection to Sonogashira coupling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alkylation
  • Alkynes / chemical synthesis*
  • Alkynes / chemistry*
  • Benzene Derivatives / chemistry*
  • Copper / chemistry*
  • Molecular Structure

Substances

  • Alkynes
  • Benzene Derivatives
  • Copper