[Intra-detrusor injection of botulinum toxin for female refractory idiopathic overactive bladder syndrome]

Abstract

Introduction: Botulinum toxin-A detrusor injections are now approved for use (extension of marketing authorization) in the management of refractory idiopathic overactive bladder. The goal of the current study was to study the value and efficacy of this therapy.

Patients and methods: A literature review was performed on Medline, Embase and Cochrane databases, using the following keywords: botulinum toxin; overactive bladder syndrome; urinary incontinence; detrusor injection.

Results: The recommended first step dose is 50 units of BOTOX(©) (dose selected for tolerance assessment). However, the cure rates for urge incontinence are greater with 100 units. Before proposing an injection, it is recommended to ensure the feasibility and acceptability of self-catheterisation by the patient, because of the risk of urinary retention (6%). The administration of BOTOX(©) comprises an intra-detrusor injection using a cystoscope, performed under local anesthesia. Clinical improvement is generally observed in the first two weeks after the injection. Patients should be considered for reinjection when the clinical effect of the previous injection has diminished, approximately 6-9 months after the first injection. An injection of 100 units may be considered when the clinical benefit of the 50-unit injection is not satisfactory concerning incontinence symptoms.

Conclusion: Botulinum toxin detrusor injections may be offered to women who develop refractory OAB.

Keywords: Botulinum toxin; Hyperactivité vésicale; Incontinence sur urgenturies; Injection intra-détruosrienne; Intra-detrusor injection; Overactive bladder syndrom; Toxine botulinique; Urge incontinence; Urinary incontinence.