Relationship between cardio-ankle vascular index and N-terminal pro-brain natriuretic peptide in hypertension and coronary heart disease subjects

Hongyu Wang; Jinbo Liu; Hongwei Zhao; Yingyan Zhou; Xujing Zhao; Yuejie Song; Lihong Li; Hongyan Shi

doi:10.1016/j.jash.2014.05.009

Relationship between cardio-ankle vascular index and N-terminal pro-brain natriuretic peptide in hypertension and coronary heart disease subjects

J Am Soc Hypertens. 2014 Sep;8(9):637-43. doi: 10.1016/j.jash.2014.05.009. Epub 2014 May 28.

Authors

Hongyu Wang¹, Jinbo Liu², Hongwei Zhao², Yingyan Zhou², Xujing Zhao², Yuejie Song², Lihong Li², Hongyan Shi²

Affiliations

¹ Department of Vascular Medicine, Peking University Shougang Hospital, Beijing, P. R. of China. Electronic address: hongyuwang@188.com.
² Department of Vascular Medicine, Peking University Shougang Hospital, Beijing, P. R. of China.

PMID: 25081196
DOI: 10.1016/j.jash.2014.05.009

Abstract

Arterial stiffness is an independent predictor for vascular diseases. Cardio-ankle vascular index (CAVI) is a new index of arterial stiffness. N-terminal pro-brain natriuretic peptide (NT-proBNP) is a strong prognostic marker in advanced stage of coronary heart disease (CHD). In the present study, we investigated the relationship between CAVI and NT-proBNP in hypertension and CHD subjects. Five hundred one subjects (male/female, 209/292) from Vascular Medicine of Peking University Shougang Hospital were divided into four groups: healthy group (n = 186), hypertension group (n = 159), CHD group (n = 45), and hypertension with CHD group (n = 111). CAVI was measured using VS-1000 apparatus. Our results showed that CAVI was significantly higher in hypertension subjects with CHD than in healthy and hypertension group, respectively (8.42 ± 1.51 vs. 7.77 ± 1.19; 8.42 ± 1.51 vs. 7.92 ± 1.11; both P < .05). NT-proBNP was significantly higher in hypertension subjects with CHD than in healthy, hypertension, and CHD group, respectively (422.48 ± 761.60 vs. 174.29 ± 415.48; 422.48 ± 761.60 vs. 196.14 ± 299.16; 422.48 ± 761.60 vs. 209.66 ± 242.66; all P < .05). And after log transformation of NT-proBNP, this phenomenon also exists (2.32 ± 0.47 vs. 2.03 ± 0.40; 2.32 ± 0.47 vs. 2.09 ± 0.44; 2.32 ± 0.47 vs. 2.12 ± 0.42; all P < .05). There was positive correlation between log NT-proBNP and CAVI in the entire study group, healthy group, and nonhealthy group (r = 0.235, P < .001; r = 0.184, P = .023; r = 0.237, P < .001; respectively). Multivariate analysis showed that NT-proBNP was an independent associating factor of CAVI in all subjects (β = 0.150, P = .021). Our present study showed that CAVI and NT-proBNP were significantly higher in hypertension subjects with CHD compared with healthy and hypertension groups. There was significant correlation between NT-proBNP and CAVI, which indicates the relationship between arterial stiffness and biomarkers in vascular-related diseases.

Keywords: Arterial stiffness; Biomarkers.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Ankle / blood supply
Biomarkers / blood
Blood Pressure / physiology*
Coronary Artery Disease / blood
Coronary Artery Disease / complications
Coronary Artery Disease / physiopathology*
Electrocardiography*
Female
Follow-Up Studies
Humans
Hypertension / blood
Hypertension / complications
Hypertension / physiopathology*
Male
Middle Aged
Natriuretic Peptide, Brain / blood*
Peptide Fragments / blood*
Protein Precursors
Retrospective Studies
Vascular Stiffness / physiology*

Substances

Biomarkers
Peptide Fragments
Protein Precursors
pro-brain natriuretic peptide (1-76)
Natriuretic Peptide, Brain