Xenortide Biosynthesis by Entomopathogenic Xenorhabdus nematophila

Daniela Reimer; Friederike I Nollmann; Katharina Schultz; Marcel Kaiser; Helge B Bode

doi:10.1021/np500390b

Xenortide Biosynthesis by Entomopathogenic Xenorhabdus nematophila

J Nat Prod. 2014 Aug 22;77(8):1976-80. doi: 10.1021/np500390b.

Authors

Daniela Reimer¹, Friederike I Nollmann¹, Katharina Schultz¹, Marcel Kaiser², Helge B Bode¹

Affiliations

¹ Merck Stiftungsprofessur für Molekulare Biotechnologie, Fachbereich Biowissenschaften, Goethe Universität Frankfurt , 60438 Frankfurt am Main, Germany.
² Swiss Tropical and Public Health Institute , Parasite Chemotherapy Socinstraße 57, P.O. Box, CH-4002 Basel, Switzerland.

PMID: 25080196
DOI: 10.1021/np500390b

Abstract

The biosynthesis gene cluster of the xenortides and a new derivative, xenortide D, which is produced in only trace amounts, was identified in Xenorhabdus nematophila. The structure of xenortide D was elucidated using a combination of labeling experiments followed by MS analysis and was confirmed by synthesis. Bioactivity tests revealed a weak activity of tryptamine-carrying xenortides against Plasmodium falciparum and Trypanosoma brucei.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromatography, High Pressure Liquid
Dipeptides / chemistry
Dipeptides / metabolism*
Dipeptides / pharmacology
Leishmania / drug effects
Molecular Structure
Multigene Family
Nuclear Magnetic Resonance, Biomolecular
Parasitic Sensitivity Tests
Plasmodium falciparum / drug effects
Trypanosoma brucei brucei / drug effects
Tryptamines / chemistry
Xenorhabdus / chemistry*

Substances

Dipeptides
Tryptamines
xenortide D