Human dominant disease genes are enriched in paralogs originating from whole genome duplication

Param Priya Singh; Séverine Affeldt; Giulia Malaguti; Hervé Isambert

doi:10.1371/journal.pcbi.1003754

Human dominant disease genes are enriched in paralogs originating from whole genome duplication

PLoS Comput Biol. 2014 Jul 31;10(7):e1003754. doi: 10.1371/journal.pcbi.1003754. eCollection 2014 Jul.

Authors

Param Priya Singh¹, Séverine Affeldt¹, Giulia Malaguti¹, Hervé Isambert¹

Affiliation

¹ CNRS-UMR168, UPMC, Institut Curie, Research Center, Paris, France.

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Disease / genetics*
Genes, Duplicate / genetics*
Genome, Human / genetics*
Humans

Grants and funding

PPS acknowledges a PhD fellowship from Erasmus Mundus (Université Pierre et Marie Curie) and La Ligue Contre Le Cancer; SA and GM acknowledge a PhD fellowship from Ministry of Higher Education and Research. HI acknowledges funding from Foundation Pierre-Gilles de Gennes. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.