Cysteine-selective reactions for antibody conjugation

Abstract

Moving tracks from maleimide: New site-selective protein modification reactions at cysteine have been developed. Unlike conventional maleimide conjugation, which results in a labile thioether succinimide, the new bioconjugation reactions result in stable conjugates and provide opportunities to develop a new generation of homogeneous, stable, and therapeutically useful conjugates.

Keywords: antibodies; bioorganic chemistry; conjugation; drug delivery; maleimides.