Cyclodextrin polyrotaxanes as a highly modular platform for the development of imaging agents

Chemistry. 2014 Aug 25;20(35):10915-20. doi: 10.1002/chem.201403635. Epub 2014 Jul 28.

Abstract

Selectively functionalized cyclodextrins with a bodipy fluorescent tag or Gd(3+) complex were synthetized and threaded onto a polyammonium chain to form polyrotaxanes. This modular supramolecular assembly makes an ideal platform for bimodal (fluorescent and MRI) imaging applications.

Keywords: bimodal imaging; cyclodextrin; polyrotaxane.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Coordination Complexes / chemistry*
  • Cyclodextrins / chemistry*
  • Fluorescent Dyes / chemical synthesis*
  • Fluorescent Dyes / chemistry*
  • Gadolinium / chemistry*
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Rotaxanes / chemistry*

Substances

  • Coordination Complexes
  • Cyclodextrins
  • Fluorescent Dyes
  • Rotaxanes
  • Gadolinium