Abstract
A crystal structure of lysozyme in complex with p-sulfonato-calix[4]arene (sclx4) reveals a linear assembly of protein tetramers glued together by protein-calixarene interactions. One interaction involves encapsulation of the highly exposed C-terminal Arg128. The other involves an intricate protein-bound complex of sclx4, Mg(2+) and a fragment of polyethylene glycol.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Binding Sites
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Calixarenes / chemistry*
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Calixarenes / metabolism
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Crystallography, X-Ray
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Molecular Dynamics Simulation
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Muramidase / chemistry*
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Muramidase / metabolism
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Phenols / chemistry*
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Phenols / metabolism
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Polyethylene Glycols / chemistry
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Polyethylene Glycols / metabolism
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Protein Binding
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Protein Structure, Quaternary
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Sulfonic Acids / chemistry*
Substances
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Phenols
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Sulfonic Acids
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calix(4)arene
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Calixarenes
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Polyethylene Glycols
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Muramidase