Fecal volatile organic compounds: a novel, cheaper method of diagnosing inflammatory bowel disease?

Expert Rev Clin Immunol. 2014 Sep;10(9):1129-31. doi: 10.1586/1744666X.2014.943664. Epub 2014 Jul 28.

Abstract

The investigation of a novel, cheaper method of diagnosing inflammatory bowel disease (IBD) is an area of active research. Recently, investigations into the metabolomic profile of IBD patients and animal models of colitis compared to healthy controls has begun to receive considerable attention and correlations between the fecal volatile organic compound (VOC) metabolome and IBD is merging. Patients and clinicians have often reported a change in odor of feces during relapse of IBD. Therefore, this article will focus specifically on the fecal VOC metabolome and its potential role in identifying a novel diagnostic method for IBD.

Keywords: diagnostic; feces; inflammatory bowel disease; novel; volatile organic compound.

Publication types

  • Editorial

MeSH terms

  • Animals
  • Disease Models, Animal
  • Feces / chemistry*
  • Feces / microbiology
  • Humans
  • Inflammatory Bowel Diseases / diagnosis*
  • Inflammatory Bowel Diseases / immunology
  • Inflammatory Bowel Diseases / microbiology
  • Intestinal Mucosa / metabolism*
  • Intestines / immunology
  • Intestines / microbiology
  • Metabolome* / immunology
  • Microbiota
  • Odorants / analysis
  • Volatile Organic Compounds / analysis*
  • Volatile Organic Compounds / immunology

Substances

  • Volatile Organic Compounds