Intra-periaqueductal gray infusion of zeta inhibitory peptide attenuates pain-conditioned place avoidance in rats

Jianliang Sun; Bo Lu; Juan Yao; Weiping Lei; Yaqin Huang; Honghai Zhang; Chun Xiao

doi:10.1016/j.brainres.2014.07.027

Intra-periaqueductal gray infusion of zeta inhibitory peptide attenuates pain-conditioned place avoidance in rats

Brain Res. 2014 Sep 25:1582:55-63. doi: 10.1016/j.brainres.2014.07.027. Epub 2014 Jul 24.

Authors

Jianliang Sun¹, Bo Lu², Juan Yao³, Weiping Lei³, Yaqin Huang³, Honghai Zhang¹, Chun Xiao⁴

Affiliations

¹ Department of Anesthesia, Hangzhou Hospital Affiliated to Nanjing Medical University, Hangzhou First People׳s Hospital, Hangzhou 310006, PR China.
² Department of Anesthesia, Ningbo Second Hospital, Ningbo 315000, PR China.
³ Department of Anesthesia, Second Affiliated Hospital and Yuying Children Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
⁴ Department of Anesthesia, Hangzhou Hospital Affiliated to Nanjing Medical University, Hangzhou First People׳s Hospital, Hangzhou 310006, PR China; Department of Anesthesia, Jiaxing First Hospital, Jiaxing 314000, PR China. Electronic address: xiaochunmz@gmail.com.

PMID: 25065981
DOI: 10.1016/j.brainres.2014.07.027

Abstract

Pain is a complex experience that made up of sensory, emotional and cognitive dimensions, and the emotional factors have an important influence on intensity of pain perception. The role of periaqueductal gray (PAG) in sensory component of pain has been extensively studied, while data about pain affect are quite limited. Using formalin-induced conditioned place avoidance (F-CPA) test and inflammatory pain model, present study investigated the effect of intra-PAG infusion of zeta inhibitory peptide (ZIP) on noxious stimulation induced aversion, and the sensory component of pain. Intra-PAG injection of ZIP is sufficient to disrupt pain-induced aversion, but the ZIP infusion did not change inflammation induced pain hypersensitivity in rats. These findings suggest that PAG contributes to pain-related aversion in rats, and the mechanism of pain emotion encoding in PAG may attribute to the activation of targets of ZIP.

Keywords: Conditioned place avoidance; Nociceptive behavior; Pain; Periaqueductal gray.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Analgesics / administration & dosage*
Animals
Avoidance Learning / drug effects*
Avoidance Learning / physiology
Cell-Penetrating Peptides
Conditioning, Psychological / drug effects
Conditioning, Psychological / physiology
Disease Models, Animal
Formaldehyde
Freund's Adjuvant
Hyperalgesia / drug therapy
Hyperalgesia / physiopathology
Lipopeptides / administration & dosage*
Male
Neuroimmunomodulation / drug effects
Neuroimmunomodulation / physiology
Pain / drug therapy*
Pain / physiopathology
Pain Measurement
Periaqueductal Gray / drug effects*
Periaqueductal Gray / physiopathology
Rats, Sprague-Dawley
Space Perception / drug effects*
Space Perception / physiology

Substances

Analgesics
Cell-Penetrating Peptides
Lipopeptides
zeta-inhibitory peptide
Formaldehyde
Freund's Adjuvant