Intact IL-12 signaling is necessary for the generation of human natural killer cells with enhanced effector function after restimulation

Affiliations

• ¹ Laboratory of Molecular and Developmental Immunology, Division of Monoclonal Antibodies, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Md.
• ² BioCruces Health Research Institute, Barakaldo, Spain.
• ³ University of Wisconsin School of Medicine and Public Health, Madison, Wis.
• ⁴ Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
• ⁵ Immunology Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Md.
• ⁶ Primary Immunodeficiency Clinic, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
• ⁷ Laboratory of Molecular and Developmental Immunology, Division of Monoclonal Antibodies, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Md; BioCruces Health Research Institute, Barakaldo, Spain; Ikerbasque, Basque Foundation for Science, Bilbao, Spain. Electronic address: francisco.borregorabasco@osakidetza.net.