We studied the intracerebral dynamics of developing skills for self-regulation of psychophysiological functions in the biofeedback game model via functional MRI. Multiple game plots managed by physiological characteristics leave a trace in the form of activity zones in the middle occipital gyrus, middle temporal gyrus, middle frontal gyrus, inferior parietal lobule, and declive functionally related to cognitive actions and operations. During the development of self-regulation skills, the gradual shift of the localization of areas of activity is observed towards sensory projection fields (e.g., thalamus, superior parietal lobule), which indicates distribution of the load toward the perceptual areas.