Rapid engineering of versatile molecular logic gates using heterologous genetic transcriptional modules

Chem Commun (Camb). 2014 Oct 11;50(79):11642-4. doi: 10.1039/c4cc05264a.

Abstract

We designed and constructed versatile modular genetic logic gates in bacterial cells. These function as digital logic 1-input Buffer gate, 2-input and 3-input AND gates with one inverted input and integrate multiple chemical input signals in customised logic manners. Such rapidly engineered devices serve to achieve increased sensing signal selectivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arsenites
  • Bacterial Proteins / genetics
  • Computers, Molecular*
  • DNA-Binding Proteins / genetics
  • Escherichia coli / genetics*
  • Logic
  • Pseudomonas syringae / genetics*
  • Transcription Factors / genetics
  • Transcription, Genetic

Substances

  • Arsenites
  • Bacterial Proteins
  • DNA-Binding Proteins
  • HrpR protein, Pseudomonas syringae
  • Transcription Factors
  • hrpS protein, Pseudomonas syringae
  • arsenite