Silencing is noisy: population and cell level noise in telomere-adjacent genes is dependent on telomere position and sir2

PLoS Genet. 2014 Jul 24;10(7):e1004436. doi: 10.1371/journal.pgen.1004436. eCollection 2014 Jul.

Abstract

Cell-to-cell gene expression noise is thought to be an important mechanism for generating phenotypic diversity. Furthermore, telomeric regions are major sites for gene amplification, which is thought to drive genetic diversity. Here we found that individual subtelomeric TLO genes exhibit increased variation in transcript and protein levels at both the cell-to-cell level as well as at the population-level. The cell-to-cell variation, termed Telomere-Adjacent Gene Expression Noise (TAGEN) was largely intrinsic noise and was dependent upon genome position: noise was reduced when a TLO gene was expressed at an ectopic internal locus and noise was elevated when a non-telomeric gene was expressed at a telomere-adjacent locus. This position-dependent TAGEN also was dependent on Sir2p, an NAD+-dependent histone deacetylase. Finally, we found that telomere silencing and TAGEN are tightly linked and regulated in cis: selection for either silencing or activation of a TLO-adjacent URA3 gene resulted in reduced noise at the neighboring TLO but not at other TLO genes. This provides experimental support to computational predictions that the ability to shift between silent and active chromatin states has a major effect on cell-to-cell noise. Furthermore, it demonstrates that these shifts affect the degree of expression variation at each telomere individually.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Communication / genetics
  • Chromatin / genetics
  • DNA-Binding Proteins / biosynthesis*
  • DNA-Binding Proteins / genetics
  • Gene Expression Regulation, Fungal / genetics
  • Histone Deacetylases / genetics
  • Histone Deacetylases / metabolism
  • Protein Processing, Post-Translational / genetics
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins / genetics
  • Silent Information Regulator Proteins, Saccharomyces cerevisiae / genetics*
  • Silent Information Regulator Proteins, Saccharomyces cerevisiae / metabolism
  • Sirtuin 2 / genetics*
  • Sirtuin 2 / metabolism
  • Telomere / genetics*
  • Transcription, Genetic*

Substances

  • Chromatin
  • DNA-Binding Proteins
  • Saccharomyces cerevisiae Proteins
  • Silent Information Regulator Proteins, Saccharomyces cerevisiae
  • URA3 protein, S cerevisiae
  • SIR2 protein, S cerevisiae
  • Sirtuin 2
  • Histone Deacetylases