Abstract
We describe herein the synthesis and immunological evaluation of self-adjuvanting mucin 1 (MUC1)-macrophage activating lipopeptide 2 (MALP2) (glyco)peptide vaccine candidates. Vaccine constructs were shown to induce high titres of class-switched IgG antibodies in C57BL/6 mice after four immunisations despite the lack of a helper T cell epitope.
MeSH terms
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Adjuvants, Immunologic / chemical synthesis*
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Animals
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Autoantibodies / immunology
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Cancer Vaccines / chemical synthesis*
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Cancer Vaccines / immunology
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Drug Evaluation, Preclinical / methods
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Lipopeptides / administration & dosage
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Lipopeptides / chemical synthesis*
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Lipopeptides / immunology
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Mice
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Mice, Inbred C57BL
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Mucin-1* / administration & dosage
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Mucin-1* / immunology
Substances
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Adjuvants, Immunologic
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Autoantibodies
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Cancer Vaccines
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Lipopeptides
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Mucin-1
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muc1 protein, mouse
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macrophage stimulatory lipopeptide 2