Extreme early-life anxiety is associated with an evolutionarily conserved reduction in the strength of intrinsic functional connectivity between the dorsolateral prefrontal cortex and the central nucleus of the amygdala

R M Birn; A J Shackman; J A Oler; L E Williams; D R McFarlin; G M Rogers; S E Shelton; A L Alexander; D S Pine; M J Slattery; R J Davidson; A S Fox; N H Kalin

doi:10.1038/mp.2014.85

Extreme early-life anxiety is associated with an evolutionarily conserved reduction in the strength of intrinsic functional connectivity between the dorsolateral prefrontal cortex and the central nucleus of the amygdala

Mol Psychiatry. 2014 Aug;19(8):853. doi: 10.1038/mp.2014.85.

Authors

R M Birn¹, A J Shackman², J A Oler³, L E Williams³, D R McFarlin⁴, G M Rogers⁵, S E Shelton⁵, A L Alexander⁶, D S Pine⁷, M J Slattery⁵, R J Davidson⁸, A S Fox⁹, N H Kalin¹⁰

Affiliations

¹ 1] Department of Medical Physics, University of Wisconsin, Madison, WI, USA [2] Department of Psychiatry, University of Wisconsin, Madison, WI, USA [3] HealthEmotions Research Institute, University of Wisconsin, Madison, WI, USA [4] Lane Neuroimaging Laboratory, University of Wisconsin, Madison, WI, USA [5] Waisman Laboratory for Brain Imaging and Behavior, University Wisconsin, Madison, WI, USA.
² 1] Department of Psychology, University of Maryland, College Park, MD, USA [2] Neuroscience and Cognitive Science Program, University of Maryland, College Park, MD, USA [3] Maryland Neuroimaging Center, University of Maryland, College Park, MD, USA.
³ 1] Department of Psychiatry, University of Wisconsin, Madison, WI, USA [2] HealthEmotions Research Institute, University of Wisconsin, Madison, WI, USA [3] Lane Neuroimaging Laboratory, University of Wisconsin, Madison, WI, USA.
⁴ 1] Department of Psychiatry, University of Wisconsin, Madison, WI, USA [2] HealthEmotions Research Institute, University of Wisconsin, Madison, WI, USA [3] Lane Neuroimaging Laboratory, University of Wisconsin, Madison, WI, USA [4] Waisman Laboratory for Brain Imaging and Behavior, University Wisconsin, Madison, WI, USA.
⁵ Department of Psychiatry, University of Wisconsin, Madison, WI, USA.
⁶ 1] Department of Medical Physics, University of Wisconsin, Madison, WI, USA [2] Waisman Laboratory for Brain Imaging and Behavior, University Wisconsin, Madison, WI, USA.
⁷ Section on Development and Affective Neuroscience, National Institute of Mental Health, Bethesda, MD, USA.
⁸ 1] Department of Psychiatry, University of Wisconsin, Madison, WI, USA [2] HealthEmotions Research Institute, University of Wisconsin, Madison, WI, USA [3] Waisman Laboratory for Brain Imaging and Behavior, University Wisconsin, Madison, WI, USA [4] Department of Psychology, University of Wisconsin, Madison, WI, USA [5] Center for Investigating Healthy Minds, University of Wisconsin, Madison, WI, USA.
⁹ 1] Department of Psychiatry, University of Wisconsin, Madison, WI, USA [2] HealthEmotions Research Institute, University of Wisconsin, Madison, WI, USA [3] Lane Neuroimaging Laboratory, University of Wisconsin, Madison, WI, USA [4] Waisman Laboratory for Brain Imaging and Behavior, University Wisconsin, Madison, WI, USA [5] Department of Psychology, University of Wisconsin, Madison, WI, USA [6] Center for Investigating Healthy Minds, University of Wisconsin, Madison, WI, USA.
¹⁰ 1] Department of Psychiatry, University of Wisconsin, Madison, WI, USA [2] HealthEmotions Research Institute, University of Wisconsin, Madison, WI, USA [3] Lane Neuroimaging Laboratory, University of Wisconsin, Madison, WI, USA [4] Waisman Laboratory for Brain Imaging and Behavior, University Wisconsin, Madison, WI, USA [5] Department of Psychology, University of Wisconsin, Madison, WI, USA.

No abstract available

MeSH terms

Age Factors
Aging / physiology
Aging / psychology
Animals
Anxiety Disorders / physiopathology*
Biological Evolution*
Brain Mapping
Central Amygdaloid Nucleus / physiopathology*
Child
Haplorhini
Humans
Neural Pathways / physiopathology
Prefrontal Cortex / physiopathology*

MeSH terms

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