A micro RNA-146a polymorphism is associated with coronary restenosis

Int J Immunogenet. 2014 Oct;41(5):393-6. doi: 10.1111/iji.12136. Epub 2014 Jul 22.

Abstract

The association of the miRNA-146a polymorphism rs2910164 with atherosclerosis and restenosis was investigated. We found no association with atherosclerosis; however, we found a negative association for the G/C (P = 0.007) and a positive association for the C/C genotype with the risk of restenosis, which is the main drawback for cardiac surgery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alleles
  • Case-Control Studies
  • Coronary Disease / genetics
  • Coronary Restenosis / genetics*
  • Female
  • Genetic Association Studies*
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Male
  • MicroRNAs / genetics*
  • Middle Aged
  • Odds Ratio
  • Polymorphism, Genetic*

Substances

  • MIRN146 microRNA, human
  • MicroRNAs