Diaporine, a novel endophyte-derived regulator of macrophage differentiation

Org Biomol Chem. 2014 Sep 14;12(34):6545-8. doi: 10.1039/c4ob01123f.

Abstract

Diaporine (1), an unprecedented symmetric polyketide, was characterized from the endophytic fungus. The structure was determined by extensive spectroscopic analyses. Diaporine can inhibit significantly the differentiation of macrophages and has potential to induce conversion from the M2 to the M1 phenotype, in addition to regulation of the TLR4-MAPK signal pathway and PPARγ activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Factors
  • Cell Differentiation / drug effects*
  • Chromones / chemistry
  • Chromones / isolation & purification
  • Chromones / pharmacology*
  • Cytokines / genetics
  • Cytokines / metabolism
  • Endophytes / chemistry*
  • Fungi / chemistry*
  • Gene Expression Regulation
  • MAP Kinase Kinase 4 / genetics
  • MAP Kinase Kinase 4 / metabolism
  • Macrophages / cytology
  • Macrophages / drug effects*
  • Macrophages / metabolism
  • Mice
  • Mitogen-Activated Protein Kinase 1 / genetics
  • Mitogen-Activated Protein Kinase 1 / metabolism
  • Mitogen-Activated Protein Kinase 3 / genetics
  • Mitogen-Activated Protein Kinase 3 / metabolism
  • PPAR gamma / genetics
  • PPAR gamma / metabolism
  • Phenotype
  • Polyketides / chemistry
  • Polyketides / isolation & purification
  • Polyketides / pharmacology*
  • Primary Cell Culture
  • Rhizophoraceae / microbiology
  • Signal Transduction
  • Symbiosis
  • Toll-Like Receptor 4 / genetics
  • Toll-Like Receptor 4 / metabolism

Substances

  • Biological Factors
  • Chromones
  • Cytokines
  • PPAR gamma
  • Polyketides
  • Tlr4 protein, mouse
  • Toll-Like Receptor 4
  • diaporine
  • Mitogen-Activated Protein Kinase 1
  • Mitogen-Activated Protein Kinase 3
  • MAP Kinase Kinase 4